DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes via three nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic condition syndromes. Crystal constructions of DNA ligases certain to nucleotide and nucleic acid substrates have illuminated how ligase response chemistry is catalyzed, how ligases identify destroyed DNA ends, and how protein area actions and Energetic-site remodeling are used to choreograph the end-joining pathway.

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) so the concave surface from the OB β-barrel fits to the DNA minor groove. This transition elicits a 63-Å movement of the OB domain and destinations the latch deep from the DNA major groove.